Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination
نویسندگان
چکیده
منابع مشابه
Mimicking phosphorylation of αB-crystallin affects its chaperone activity
Heath ECROYD*, Sarah MEEHAN*, Joseph HORWITZ†, J. Andrew AQUILINA‡, Justin L. P. BENESCH§, Carol V. ROBINSON§, Cait E. MACPHEE‖ and John A. CARVER*1 *School of Chemistry and Physics, University of Adelaide, Adelaide, SA 5005, Australia, †Jules Stein Institute, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095-7008, U.S.A., ‡School of Biological Sciences, Universit...
متن کاملPhosphorylation-induced Change of the Oligomerization State of αB-crystallin*
aB-crystallin in cells can be phosphorylated at three serine residues in response to stress or during mitosis (Ito, H., Okamoto, K., Nakayama, H., Isobe, T., and Kato, K. (1997) J. Biol. Chem. 272, 29934–29941 and Kato, K., Ito, H., Kamei, K., Inaguma, Y., Iwamoto, I., and Saga, S. (1998) J. Biol. Chem. 273, 28346–28354). In the present study, we determined effects of phosphorylation of aBcryst...
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We have previously shown that αB-crystallin (CRYAB), a small heat shock protein (sHsp) that prevents irreversible aggregation of unfolded protein by an ATP-independent chaperone activity, plays a pivotal role in the biogenesis of multipass transmembrane proteins (TMPs) assisting their folding from the cytosolic side of the endoplasmic reticulum (ER) (D'Agostino et al., 2013). Here we present ev...
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Protein quality control (PQC) plays a key role in maintaining cardiomyocyte function and homeostasis, and malfunction in PQC is implicated in various forms of heart diseases. Molecular chaperones serve as the primary checkpoint for PQC; however, their roles in the pathogenesis of viral myocarditis, an inflammation of the myocardium caused by viral infection, are largely unknown. AlphaB-crystall...
متن کاملCorrection: In Vivo Substrates of the Lens Molecular Chaperones αA-Crystallin and αB-Crystallin
αA-crystallin and αB-crystallin are members of the small heat shock protein family and function as molecular chaperones and major lens structural proteins. Although numerous studies have examined their chaperone-like activities in vitro, little is known about the proteins they protect in vivo. To elucidate the relationships between chaperone function, substrate binding, and human cataract forma...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1621314114